Nanoparticles guided drug delivery and imaging in gastric cancer

Publication date: Available online 16 January 2020Source: Seminars in Cancer BiologyAuthor(s): Ganji Purnachandra Nagaraju, Gowru Srivani, Begum Dariya, Gayathri Chalikonda, Batoul Farran, Santosh Kumar Behera, Afroz Alam, Mohammad Amjad KamalAbstractGastric cancer represents a deadly malignancy worldwide, yet current therapeutic regimens remain ineffective. Nanoparticle (NP) -based solutions could allow the design of novel therapeutic methods to eliminate this fatal disease. NPs typically carry out a significant role in multifunctional, multimodal imaging, and drug delivery carriers. In the recent decade, they have emerged as candidate approaches for the design of novel treatment strategies. Tumor nanotherapeutics characteristically possess various distinct advantages compared to conventional anti-cancer medications, which suffer from nonspecific bio-distribution, low solubility, and poor bioavailability. In this review, we will discuss the application of NPs in diagnosis and controlled drug delivery in gastric cancer (GC). We will focus on various NPs-based strategies employed against GC.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research