Tumor-suppressor microRNA-151-5p regulates the growth, migration and invasion of human breast cancer cells by inhibiting SCOS5.

This study was designed to investigate the role and therapeutic implications of miR-151-5p in breast cancer. The results of the present study revealed that miR-151-5p is significantly downregulated in breast cancer tissues and cell lines. Overexpression of miR-151-5p in SK-BR-3 and CAMA-1 cells inhibits their proliferation and colony formation. Wound heal and transwell assays showed that miR-151-5p inhibits the migration and invasion of the SK-BR-3 and CAMA-1 breast cancer cells. TargetScan analysis followed by the dual luciferase assay confirmed SOCS5 to be the target of miR-151-5p in breast cancer. The expression of SOCS5 was upregulated in all the breast cancer tissues and cell lines. Silencing of SOC5 caused significant inhibition in the proliferation, migration and invasion of the SK-BR-3 cells. Nonetheless, overexpression of SCOS5 could avoid the growth inhibitory effects of miR-151-5p on the breast cancer cells. To conclude, miR-151-5p acts as a tumor suppressor in breast cancer and may exhibit therapeutic implications. PMID: 31934285 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research