Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance [Neuroscience]

Ankyrin-G (AnkG), a highly enriched scaffold protein in the axon initial segment (AIS) of neurons, functions to maintain axonal polarity and the integrity of the AIS. At the AIS, AnkG regulates selective intracellular cargo trafficking between soma and axons via interaction with the dynein regulator protein Ndel1, but the molecular...

http://www.pnas.org/content/117/2/1207.short?rss=1

Source: Proceedings of the National Academy of Sciences - January 13, 2020 Category: Science Authors: Jin Ye, Jianchao Li, Fei Ye, Yan Zhang, Mingjie Zhang, Chao Wang Tags: Biological Sciences Source Type: research