Ischemic Stroke with Protein S Deficiency Treated by Apixaban

A 57-year-old man with atherosclerosis obliterans was admitted with sudden-onset sensory aphasia and right hemiparesis. Brain MRI revealed acute cerebral infarctions in the left temporal lobe and magnetic resonance angiography showed occlusion of the posterior branch of the left middle cerebral artery. Transesophageal echocardiography and ultrasonography respectively confirmed a patent foramen ovale and deep vein thrombosis in the bilateral femoral veins. Blood findings showed low protein S antigen, low protein S activity, and a missense mutation of the PROS 1 gene.

Source: Journal of Stroke and Cerebrovascular Diseases - January 12, 2020 Category: Neurology Authors: Ikkei Ohashi, Shinichi Wada, Fumitaka Yoshino, Takahiro Kuwashiro, Shinya Matsumoto, Taeko Hotta, Dongchong Kang, Yasushi Okada, Shun Shimohama, Masahiro Yasaka Tags: Case Report Source Type: research