Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya

Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research

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In this study, we detected in Northern Africa two putatively novel Rickettsia species in soft tick species of the Ornithodoros erraticus complex: Ornithodoros occidentalis from Morocco, Ornithodoros erraticus from Algeria and Ornithodoros normandi from Tunisia. We characterized these two novel Rickettsia species on the basis of comparative DNA sequence analyses and phylogenetics of four genes (gltA, 16S rRNA, coxA and ompB). These Rickettsia, provisionally named ‘Candidatus Rickettsia africaseptentrionalis’ and ‘Candidatus Rickettsia mauretanica’, differed in nucleotide sequence from those of other ...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
CONCLUSION: The diagnosis of PIGCH remains clinically challenging and requires a high index of suspicion as well as a thorough history, physical examination, serological workup and liver biopsy. Treatment of the underlying cause can result in clinical stability in a large number of cases. PMID: 31966907 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
CONCLUSIONS: Dpcr greatly improved the sensitivity and specificity of cccDNA detection. Host CDK activities are likely required for cccDNA synthesis. dPCR can potentially be applied for drug screening for effective cccDNA inhibitors. PMID: 31964596 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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Source: Global Public Health - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionsThis retrospective study showed that TARE therapy resulted in minimal toxicity in patients with HBV-derived HCC. Patients with CP A or BCLC A disease had superior survival outcomes compared to patients with CP B and BCLC B/C disease. These findings suggest that TARE is a viable treatment option for certain patient groups with HCC tumors secondary to HBV infection.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Individual recently travelled from the Wuhan region of China, where the virus is believed to originateLive updates on the coronavirus outbreakA Chicago woman who returned from a trip to China has been identified as the US ’s second confirmed case ofthe coronavirus. The Illinois department of health has confirmed the latest diagnosis to local news radio station WBBM.Related:'Take her out': tape appears to catch Trump demanding removal of Ukraine ambassador – liveContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak US news Chicago Science World news Source Type: news
Publication date: February 2020Source: Journal of Functional Foods, Volume 65Author(s): Yueliang Zhao, Mengru Tao, Ru Wang, Yuanqiang Guo, Mingfu WangAbstractHepatitis E virus (HEV) is one of the major causes of acute hepatitis worldwide. Here, we investigated the role of autophagy on HEV replication and demonstrated anti-HEV effects of japonicone V, a main constituent of the flowers of Inula japonica. Results showed that HEV infection induced autophagy in Huh7 cells. Chloroquine (CQ) and 3-methyladenine (3-MA), two autophagy inhibitors inhibited HEV replication. Moreover, japonicone V suppressed HEV replication and inhibi...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study is registered with ClinicalTrials.gov, NCT02409680, and the Clinical Trial Registry-India, CTRI/2016/05/006970.FindingsFrom March 23, 2016 to June 30, 2018, 14 361 women were screened for inclusion and 11 976 women aged 14–40 years were randomly assigned to receive low-dose aspirin (5990 women) or placebo (5986 women). 5780 women in the aspirin group and 5764 in the placebo group were evaluable for the primary outcome. Preterm birth before 37 weeks occurred in 668 (11·6%) of the women who took aspirin and 754 (13·1%) of those who took placebo (RR 0·89 [95% CI 0·81 to 0&middo...
Source: The Lancet - Category: General Medicine Source Type: research
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Source: AIDS Care - Category: Infectious Diseases Authors: Source Type: research
Transfusion related hepatitis C(HCV) is rare in the west, in the developing world, it remains a challenge. Children with hematological malignancies are especially vulnerable due to large number of blood components received. They often develop active hepatitis due to immunocompromised status and concurrent hepatic insults from chemotherapy and iron overload. Stem cell transplant(SCT) further increases hepatic risk due to veno-occlusive disease(VOD) and hepatic graft versus host disease(GVHD).Direct acting antivirals(DAA) have revolutionized treatment of HCV.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 536 Source Type: research
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