Recurrent Immediate Hypersensitivity Reaction to Radiocontrast Media Despite Premedication Found to Be IgE-mediated

Approximately 75 million computed tomography (CT) scans are performed with radiocontrast media (RCM) annually1 and IgE-mediated immediate hypersensitivity reactions to nonionic RCM have been reported in 0.7 to 3% of patients2. Pretreatment with prednisone and diphenhydramine has significantly reduced immediate generalized reactions to RCM3. Recently, studies suggest that skin testing can support the diagnosis of an IgE-mediated reaction to RCM and can also help guide selection of an alternative RCM if subsequent RCM exposure is anticipated1,2.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research