Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS.

Source: Autonomic Neuroscience: Basic and Clinical - January 9, 2020 Category: Neuroscience Authors: Amanda J. Miller, Lauren E. Stiles, Timothy Sheehan, Rebecca Bascom, Howard P. Levy, Clair Francomano, Amy C. Arnold Source Type: research