The opposing contribution of neurotrophin-3 and nerve growth factor to orofacial heat hyperalgesia in rats

In conclusion, we suggest that neurotrophin-3 is a potent modulator of facial heat hyperalgesia, which may exert an inhibitory influence on the trkA pathway. Neurotrophin-3 treatment may represent a promising approach, especially in pain conditions associated with increased levels of nerve growth factor.
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Research Reports Source Type: research