Complete genome analysis of avian hepatitis E virus from chicken with hepatic rupture hemorrhage syndrome

Publication date: Available online 3 January 2020Source: Veterinary MicrobiologyAuthor(s): Qi Su, Zhihui Zhang, Yawen Zhang, Zhizhong Cui, Shuang Chang, Peng ZhaoAbstractSince 2016, severe outbreaks of hepatic rupture hemorrhage syndrome (HRHS) associated with infections of tentative novel avian hepatitis E virus (HEV) have emerged in chickens in China, causing increased mortality and decreased laying rate in adult hens and disturbing the hatching and breeding of chicks. To further identify the genotype and gain a better understanding of the genetic properties of the avian HEV responsible for that, a strain from Hebei province was isolated, purified and sequenced in this study. Results identified a novel avian HEV genotype, sharing 79.5–86.9% identities with other published avian HEV strains, and having higher identities with Orthohepevirus A HEV strains. More importantly, the new isolate contains various amino-acid substitutions in its functional proteins, including methyltransferase, helicase, RNA-dependent RNA polymerase. The data presented in this report will enhance the current understanding of the genetic diversity of the avian HEV and provide additional insight into the critical factors that determine the pathogenicity.

Source: Veterinary Microbiology - January 4, 2020 Category: Veterinary Research Source Type: research