Adaption to climate change risk in eastern China: Carbon emission characteristics and analysis of reduction path

Publication date: Available online 2 January 2020Source: Physics and Chemistry of the Earth, Parts A/B/CAuthor(s): Fan Yang, Jieming Chou, Wenjie Dong, Mingyang Sun, Weixing ZhaoAbstractTo improve its ability to adapt to climate change, China has promised considerable carbon emission reduction and proposed the policy strategy of “energy revolution”. Considering the lowest carbon emission intensity and the greatest mitigation task in the Eastern Economic Zone of China, this paper analyses the change of carbon emission intensity in Eastern China from 2000 to 2015. First, to prove the significance of carbon emission intensity, this paper studies the cointegration relationship between carbon emissions and the GDP. Afterwards, from the spatiotemporal perspective, this paper decomposes and analyses the carbon emission intensity of the whole country, Eastern China and the provinces of Eastern China and quantifies the impact of different factors. This paper finds that the energy structure of China and the East was in a relatively stable state during this period. In the past, the decrease in carbon emission intensity mainly depended on the improvement of sectoral emission efficiency, and the influence of industrial structure is growing. Furthermore, changes in the eastern region are similar to those in the whole country. The eastern region needs to give full play to its economic advantage in the future. On the spatial scale, GDP per capita and the ratio of tertiary industr...
Source: Physics and Chemistry of the Earth, Parts ABC - Category: Science Source Type: research

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Publication date: Available online 22 February 2020Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Martin Wolley, Moe Thuzar, Michael StowasserAbstractAdrenal venous sampling (AVS) is a key part of the diagnostic workup of primary aldosteronism, distinguishing unilateral from bilateral disease and determining treatment options. Although AVS is a well-established procedure, many aspects remain controversial, including optimal patient selection for the procedure and exactly how AVS is performed and interpreted. Despite the controversies, a growing body of evidence supports the use of AVS ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 22 February 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Max Sauter, Philipp Uhl, Jürgen Burhenne, Walter E. HaefeliAbstractExenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus. Typical therapeutic plasma concentrations are in the low pg/mL range therefore requiring ultra-sensitive quantification. To enable the accurate evaluation of pharmacokinetic studies, we established a UPLC-MS/MS assay with a lower limit of quantification (LLOQ) of 5 pg/mL (1.2 pM) using 20...
Source: Journal of Pharmaceutical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionWhile these practices were implemented because of sound biologic plausibility or encouraging observational data, well-done RCTs have failed to show evidence of effectiveness. These examples raise caution in introducing new clinical interventions into widespread clinical practice without sufficient high quality evidence demonstrating efficacy.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
Conclusion: Taken together, these results suggest that SXD maybe alleviate EMT in DN via the inhibition of the TGF-β1/Smad/RUNX3 signaling pathway under hyperglycemic conditions.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionTaken together, the findings of in vivo and in vitro experiments proved that AESS could significantly suppress postoperative peritoneal adhesion formation through inhibiting the RhoA/ROCK signaling pathway. Our researches provide important pharmacological basis for AESS development as a potential therapeutic agent on peritoneal adhesions.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionOur data suggest that arecoline may attenuate or prevent bone loss by suppressing osteoclastogenesis and promoting osteoblastogenesis. These findings provide evidence supporting arecoline's use as a potential therapeutic agent in bone-loss disorders and diseases.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our results advance the current mechanistic understanding of the pseurotin-induced inhibition of IgE production in B-cells by linking the effect to STAT signaling, and associated modulation of B-cell proliferation and differentiation. Together with our finding that structurally simpler pseurotin analogs were able to reproduce the effects of natural pseurotins, the presented work has implications for the future research on these secondary metabolites in the context of allergic diseases.Graphical abstact
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
This study compared biointeractivity (pH of soaking water and calcium ions), porosity, water sorption, solubility, compressive strength, lap shear strength, as well as the apatite forming ability of three calcium silicate-based capping materials: Mineral trioxide aggregate (MTA), Biodentine (BD) and Tech Biosealer capping (BS).MethodsOne hundred and five discs of the tested materials were prepared in compliance with the manufacturer’s instructions. The materials' pastes were placed in Teflon molds and allowed to set before testing. The pH and Ca+2 ions were measured by a potentiometric method. Porosity, water sorptio...
Source: The Saudi Dental Journal - Category: Dentistry Source Type: research
Hospitals will be able to digitally refer recently discharged patients to community pharmacies across England for advice on new and updated prescriptions from July 2020.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 February 2020Source: Stem Cell ResearchAuthor(s): Yalan Zhou, Chengcheng Ding, Shutao Xia, Yutong Jing, Shengru Mao, Jian Liu, Juan Chen, Hon fai Chan, Shibo Tang, Jiansu ChenAbstractCrumbs homologue 1 (CRB1) mutations have been found in retinitis pigmentosa (RP) patients lead to severe retinal dystrophies. The human induced pluripotent stem (iPS) cell line CSUASOi003-A derived from peripheral blood mononuclear cells (PBMCs) of a patient carrying two heterozygous mutations (2249G>A p.G750D and c.2809G>A p.A937T) in CRB1 gene was generated by non-integrative reprogramming technolo...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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