Donor Lymphocyte Infusions after Allogeneic Transplantation: A Single Center Experience

Allogeneic hematopoietic cell transplantation (AHCT) represents the only curative therapy for many haematological malignancies. The graft-versus-leukemia effect (GVL), driven by donor Tcells plays a major role in its curative potential. This effect is sometimes very evident when AML and MDS relapses post AHCT are treated with donor lymphocyte infusions (DLI), in which lymphocytes from the original stem cell donor are infused, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted, after the transplant.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Review Article Source Type: research