Review, Historical Context, and Clarifications of the NINDS rt-PA Stroke Trials Exclusion Criteria: Part 1: Rapidly Improving Stroke Symptoms [Clinical Sciences]

Conclusions— A structured framework and quantitative approach toward defining RISS emerged through expert opinion and consensus. The term, RISS, should be reserved for those who improve to a mild deficit, specifically one which is perceived to be nondisabling. This is recommended to guide decision making on intravenous tPA eligibility going forward, including the design of future studies. An additional study of patients with rapid improvement to nonmild deficits is not justified because these patients should be treated.

http://stroke.ahajournals.org/cgi/content/short/44/9/2500?rss=1

Source: Stroke - August 26, 2013 Category: Neurology Authors: The Re-examining Acute Eligibility for Thrombolysis (TREAT) Task Force:, Levine, S. R., Khatri, P., Broderick, J. P., Grotta, J. C., Kasner, S. E., Kim, D., Meyer, B. C., Panagos, P., Romano, J., Scott, P., NINDS rt-PA Stroke Trial Investigators* Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research