A cis-element within the ARF locus mediates repression of p16INK4A expression via long-range chromatin interactions [Cell Biology]

Loss of function of CDKN2A/B, also known as INK4/ARF [encoding p16INK4A, p15INK4B, and p14ARF (mouse p19Arf)], confers susceptibility to cancers, whereas its up-regulation during organismal aging provokes cellular senescence and tissue degenerative disorders. To better understand the transcriptional regulation of p16INK4A, a CRISPR screen targeting open, noncoding chromatin regions adjacent...

Source: Proceedings of the National Academy of Sciences - December 25, 2019 Category: Science Authors: Yang Zhang, Judith Hyle, Shaela Wright, Ying Shao, Xujie Zhao, Hui Zhang, Chunliang Li Tags: PNAS Plus Source Type: research