Glioma: Targeting a histone mutant

Nature Reviews Cancer 15, 2 (2015). doi:10.1038/nrc3885 Author: Sarah Seton-Rogers Oncogenic mutation of histone H3.3 occurs frequently in paediatric brainstem gliomas. Funato et al. created a model of the aggressive brainstem glioma diffuse intrinsic pontine glioma (DIPG) using human embryonic stem cells (ESCs). Early neural progenitor cells (NPCs) were derived from ESCs and then
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research