The balance between breast cancer and the immune system: challenges for prognosis and clinical benefit from immunotherapies

Publication date: Available online 24 December 2019Source: Seminars in Cancer BiologyAuthor(s): Constantin N. Baxevanis, Sotirios P. Fortis, Sonia A. PerezAbstractCancer evolution is a complex process influenced by genetic factors and extracellular stimuli that trigger signaling pathways to coordinate the continuous and dynamic interaction between tumor cells and the elements of the immune system. For over 20 years now, the immune mechanisms controlling cancer progression have been the focus of intensive research. It is well established that the immune system conveys protective antitumor immunity by destroying immunogenic tumor variants, but also facilitates tumor progression by shaping tumor immunogenicity in a process called “immunoediting”. It is also clear that immune-guided tumor editing is associated with tumor evasion from immune surveillance and therefore reinforcing the endogenous antitumor immunity is a desired goal in the context of cancer therapies. The tumor microenvironment (TME) is a complex network which consists of various cell types and factors having important roles regarding tumor development and progression. Tumor infiltrating lymphocytes (TILs) and other tumor infiltrating immune cells (TIICs) are key to our understanding of tumor immune surveillance based on tumor immunogenicity, whereby the densities and location of TILs and TIICs in the tumor regions, as well as their functional programs (comprising the “immunoscore”) have a prominent role for...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research