Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model.

Factors influencing blood flow resistance from a large internal carotid artery aneurysm revealed by a computational fluid dynamics model. Nagoya J Med Sci. 2019 Nov;81(4):629-636 Authors: Imai T, Izumi T, Isoda H, Ishiguro K, Mizuno T, Tsukada T, Kropp A, Ito M, Nishihori M, Ishida M, Tamari Y, Wakabayashi T Abstract Hyperperfusion syndrome occurs after treatment of a large or giant cerebral aneurysm. Recently, flow-diverter stent placement has emerged as an effective treatment method for a large cerebral aneurysm, but postoperative ipsilateral delayed intraparenchymal hemorrhage occurs in a minority of cases. The mechanism underlying delayed intraparenchymal hemorrhage is not established, but one possibility is hyperperfusion syndrome. The incidence of delayed intraparenchymal hemorrhage appears to be higher for giant aneurysms; hence, we speculated that large/giant aneurysms may create flow resistance, and mitigation by flow-diverter stent deployment leads to hyperperfusion syndrome and delayed intraparenchymal hemorrhage. The purpose of this study was to identify aneurysm characteristics promoting flow resistance by the analysis of pressure loss in an internal carotid artery paraclinoid aneurysm model using computational fluid dynamics. A virtual U-shaped model of the internal carotid artery siphon portion was created with a spherical aneurysm of various angles, body diameters, and neck diameters. Visualization of streamlines, wer...
Source: Nagoya Journal of Medical Science - Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research