Loss of SMARCB1/INI1 Immunoexpression in Chordoid Meningiomas

Conclusion: This is the first study to demonstrate loss of SMARCB1/INI1 immunoexpression in chordoid meningiomas, adding to the tumors with INI1 loss. However, in absence of INI1 mutation, mechanisms for INI1 loss require further evaluation. Identification of AKT1 mutation opens up new avenues for targeted therapy in patients with such aggressive tumors.

http://www.neurologyindia.com/text.asp?2019/67/6/1492/273647

Source: Neurology India - December 19, 2019 Category: Neurology Authors: Prit B Malgulwar Aanchal Kakkar Mehar C Sharma Ranajoy Ghosh Pankaj Pathak Chitra Sarkar Vaishali Suri Manmohan Singh Shashank S Kale Mohammed Faruq Source Type: research