Benzazole substituted iminocoumarins as potential antioxidants with antiproliferative activity.

CONCLUSION: Unsubstituted benzimidazole derivatives bearing hydroxyl group on iminocoumarine nuclei exhibited the most prominent antioxidant potential in ABTS assay (3b; 40.5 ± 0.01). The most significant and selective antiproliferative activity was displayed by compounds 4d and 6b (0.059 µM; 0.17 ± 0.09, respectevly), which were chosen as lead compounds for further optimization and rational design to obtain ever more active and selective antiproliferative agents.
PMID: 31849290 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - December 16, 2019 Category: Chemistry Authors: Perin N, Cindrić M, Vervaeke P, Liekens S, Mašek T, Starčević K, Hranjec M Tags: Med Chem Source Type: research