Cholesterol as a functional metabolite cooperates with metadherin in cancer cells

This study interprets the theoretical basis of PMI-oriented cancer progression and targeting therapies in clinic.Graphical AbstractA study demonstrated and identified active protein-metabolite binding complexes through the affinity purification and followed by the successful identification and validation of the MTDH-cholesterol binding. Through the LC-MS-based metabolomics, we further defined the functional role of MTDH-cholesterol interaction in cancer cells.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research