Viruses, Vol. 12, Pages 7: TREX1 531C & gt;T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons

Viruses, Vol. 12, Pages 7: TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons Viruses doi: 10.3390/v12010007 Authors: Denis de Castro Silva Ednelza da Silva Graça Amoras Tuane Carolina Ferreira Moura Felipe Teixeira Lopes Samara Tatielle Monteiro Gomes Carlos A. da Costa Maísa Silva Sousa Ricardo Ishak Antonio Carlos Rosário Vallinoto Maria Alice Freitas Queiroz Human T-lymphotropic virus type 1 (HTLV-1) deregulates the immune system and cell cycle, resulting in loss of immune tolerance and disease, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Three prime repair exonuclease 1 (TREX1) maintains innate immune tolerance of the host and host-cell permissiveness to retroviral infections. TREX1 polymorphisms may influence the course of infection and autoimmune manifestations. The influence of TREX1 531C/T polymorphism was investigated in HTLV-1 infection and development of symptoms among 151 persons infected with HTLV-1 (32 HAM/TSP, 19 rheumatologic manifestations, two dermatitis, five more than one diagnosis, two probable HAM/TSP, and 91 asymptomatic individuals) and 100 uninfected persons in the control group. Polymorphism genotyping and proviral load quantification were performed by real-time polymerase chain reaction (PCR) and antinuclear antibodies (ANAs) were screened by an indirect immunofluorescence assay. No statistically significant difference was found in ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research