GSE116312 Expression data from biopsies with chronic atrophic gastritis and gastric cancer

Contributors : Claudia I Rivas-Ortiz ; Stephanie E Morales-Guerrero ; Sergio P de Le ón Rosales ; Armando Gamboa-Dominguez ; Claudia Rangel-Escareño ; Luis F Uscanga-Dominguez ; Germán R Aguilar-Gutiérrez ; David Kershenobich-Stalnikowitz ; Yolanda López-Vidal ; Gonzalo Castillo-RojasSeries Type : Expression profiling by arrayOrganism : Homo sapiensGastric cancer is an important health problem because it is difficult to diagnose and treat in advanced stage. This makes that the prognosis of gastric cancer patients remains scarce. Currently it is known that the cause of gastric cancer is attributed to chronic infection with Helicobacter pylori. Its persistent infection leads to development of chronic atrophic gastritis that is considered as a predecessor stage of intestinal-type gastric cancer. The understanding of the alteration of molecular mechanisms during the early stages of the development of gastric cancer, and the identification of their potential biomarkers can allow a rapid diagnosis that leads to an improvement diagnosis and increase the patient ’s prognosis. We analyzed gene expression profiles of patients with chronic atrophic gastritis and gastric cancer through microarray analysis, functional enrichment analysis and validation of gene expression by quantitative PCR.Gene expression profiles in patients with chronic atrophic gastritis showed molecular changes of the gastric mucosa, which leads to intestinal metaplasia and subsequently, gastric cancer. I...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research