Asthma and Obstructive Sleep Apnea Overlap: What has the Evidence Taught Us?

Asthma and Obstructive Sleep Apnea Overlap: What has the Evidence Taught Us? Am J Respir Crit Care Med. 2019 Dec 16;: Authors: Prasad B, Nyenhuis SM, Imayama I, Siddiqi A, Teodorescu M Abstract Obstructive sleep apnea (OSA) and asthma are highly prevalent chronic respiratory disorders. Beyond frequent coexistence arising from their high prevalence and shared risk factors, these disorders feature a reciprocal interaction, whereby each disease impacts the severity of the other. Emerging evidence implicates airway and systemic inflammation, neuroimmune interactions, as well as effects of asthma-controlling medications (corticosteroids) as factors predisposing patients with asthma to OSA. Conversely, undiagnosed or inadequately treated OSA adversely affects asthma control, partly via effects of intermittent hypoxia on airway inflammation and tissue remodeling. In this article, we review the recently published evidence supporting this interaction. We provide a set of recommendations for clinicians involved in adult asthma care and finally, identify knowledge gaps critical to advancing our understanding of this overlap. PMID: 31841642 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research