GSE142027 Hepatic microRNA Expression by PGC-1 α and PGC-1β in the Mouse II

Contributors : E Piccinin ; M Arconzo ; M Graziano ; M Vacca ; C Peres ; E Bellafante ; G Villani ; A MoschettaSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusThe fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor- γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upr egulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus Source Type: research