Contact Lens Induced Limbal Stem Cell Deficiency: Clinical Features in Korean Patients.

CONCLUSIONS: If a patient with a history of CL wear for an extended period of time presents with decreased visual acuity, practitioners should perform detailed examinations with suspicion of CL-LSCD, including fluorescein staining. CL-LSCD is usually reversible and close follow-up with conservative treatment is recommended as the initial treatment option. PMID: 31833246 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research

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In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 9 July 2019Source: Stem Cell ResearchAuthor(s): Xinyue Bai, Xian-Jie Yang, Ling ChenAbstractPathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Conclusions: NGS technology represents a powerful approach in the complex field of rare disorders but its different application should be weighted. A relatively small NGS target panel can be successfully applied for a robust diagnostic suspicion, while when the spectrum of clinical phenotypes overlaps more than one PID an in-depth NGS analysis is required, including also whole exome/genome sequencing to identify the causative gene. Introduction Primary immunodeficiencies (PIDs) are a phenotypically and genetically heterogeneous group of more than 300 monogenic inherited disorders resulting in immune defects that pred...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 December 2018Source: Stem Cell ResearchAuthor(s): Xinyue Bai, Xianjie Yang, Yun Cheng, Ling ChenAbstractPathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors expressing OCT4, SOX2, KLF4 and C-MYC. This line may provide a useful resource for exploring the pathogenesis of PM.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Educational practices may need to change to prevent damaged vision Related items fromOnMedica Eye problems: the eyelids Eye problems Eye health care placing avoidable pressure on GPs in London Two thirds of eye units restricting access to cataract surgery Stem cell 'patch' offers hope for macular degeneration
Source: OnMedica Latest News - Category: UK Health Source Type: news
In conclusion, immunohistochemistry and RT-qPCR indicated differential patterns of expression of the four adenosine receptors in the ocular tissues of the normal non-human primate. The presence of ADORs in scleral fibroblasts and the choroid may support mechanisms by which ADOR antagonists may prevent myopia. The potential effects of ADOR inhibition on both anterior and posterior ocular structures warrant investigation. PMID: 29792846 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
Publication date: Available online 28 June 2017 Source:Progress in Retinal and Eye Research Author(s): C. Ellis Wisely, Javed A. Sayed, Heather Tamez, Chris Zelinka, Mohamed H. Abdel-Rahman, Andy J. Fischer, Colleen M. Cebulla The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide range of ocular diseases and conditions. The purpose of this manuscript is to outline some anatomic, physiologic, and genetic features of this organism as a robust animal model for vision research, particularly for modeling human retinal disease. Advantages include a sequenced genome, a large eye, relative ease...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Publication date: Available online 18 August 2016 Source:Stem Cell Reports Author(s): Jonathan B. Olsen, Loksum Wong, Steven Deimling, Amanda Miles, Hongbo Guo, Yue Li, Zhaolei Zhang, Jack F. Greenblatt, Andrew Emili, Vincent Tropepe Proliferating progenitor cells undergo changes in competence to give rise to post-mitotic progeny of specialized function. These cell-fate transitions typically involve dynamic regulation of gene expression by histone methyltransferase (HMT) complexes. However, the composition, roles, and regulation of these assemblies in regulating cell-fate decisions in vivo are poorly unders...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Conclusion This paper broadens the phenotypes associated with LAMA1 mutations. We demonstrate that LAMA1 deficiency can lead to alteration in cytoskeletal dynamics, which may invariably lead to alteration in dendrite growth and axonal formation. Estimation of disease prevalence based on population studies in LAMA1 reveals a prevalence of 1–20 in 1 000 000. Trial registration number: NCT00068224
Source: Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eye Diseases, Guidelines Cognitive and behavioural genetics Source Type: research
When I lecture at anti-aging conferences around the world, I get a good sense of what the leading anti-aging physicians are thinking about. And I’m surprised by how many are still holding out hope for an anti-aging “drug.” But I’m not holding my breath. And even if the FDA approved a drug for aging, it would likely include a laundry list of side effects, and only affect a small range of age-related decline. I’ve always had more faith in nature. Many of the most powerful age fighters are naturally occurring, and they do a better job of supporting and lengthening your telomeres than any drug. Te...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Nutrition omega 3 telomere vitamin C Source Type: news
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