Premature ovarian insufficiency in adolescence: a chance for early diagnosis?
Premature ovarian insufficiency in adolescence: a chance for early diagnosis? Hormones (Athens). 2019 Dec 11;: Authors: Michala L, Stefanaki K, Loutradis D Abstract Premature ovarian insufficiency (POI) is typically diagnosed when amenorrhea is combined with high gonadotrophins and hypoestrogenemia in a woman under 40 years of age, although, more rarely, POI can develop in adolescence and present with delayed puberty or amenorrhea, depending on the timing of follicular depletion or insult to the ovary. In a proportion of girls, the diagnosis may be made at an early stage of POI, presenting with abnormal uterine bleeding, when some follicular function is still retained. The natural history of POI in this group of patients is not clear; however, they could represent a subgroup with a unique opportunity for early intervention and thus the provision of fertility preservation options. While the etiology of POI in a large number of girls remains unknown, a growing number will be identified as carriers of genetic mutations, offering clinicians a yet greater opportunity to provide genetic counseling to other female family members. The aim of this review is to provide information regarding the etiology, diagnosis, and treatment of POI in adolescents while detailing the new options for fertility preservation when POI is diagnosed at an early stage. PMID: 31828604 [PubMed - as supplied by publisher]
Conclusions The menstrual experience of individuals with DSD negatively affects their quality of life. The women with DSD in this study showed a generally poor knowledge of menarche, menstruation, and puberty, indicating that their parents had ignored the initial symptoms of DSD. DSD were only recognized at puberty because of the development of ambiguous physical traits and of the onset of menstruation in men and the confirmation of amenorrhea in women.
Abstract Objective: The aim of the study was to evaluate the correlation between obesity and the use of depot medroxyprogesterone (DMPA) with regard to weight gain and changes in bleeding pattern.Methods: A retrospective chart review was conducted of women receiving 150 mg DMPA via intramuscular injection at inpatient and outpatient clinics at the University of Mississippi Medical Centre between 1 June 2012 and 31 December 2016. Body mass indices (BMI) were assessed at baseline and at the time of final injection. Data on race, medical history, age at first DMPA injection, number and timing of injections, re...
ConclusionWe report a case of CSP that, following an initial apparently “successful” treatment with methotrexate, required surgical management due to heavy bleeding.
ConclusionUltrasound-guided local injection of MTX is an effective and minimally invasive treatment for CSP. However, it is not feasible for patients with long-term amenorrhea (>8 weeks) and markedly increased blood βHCG level.
ConclusionWith its flexibility and smaller size over other devices minimizing the need for cervical dilatation and patient discomfort, the use of Minitouch for outpatient treatment of HMB at our center was shown to be well-tolerated, with high reliability of procedure completion, good safety and efficacy outcomes.
ConclusionsIntrauterine Bigatti Shaver® is a feasible technique for placental remnants removal. Further studies comparing various surgical treatment are needed to define which technique is the safest and completely remove placental remnants.
CONCLUSION: We found both objective and subjective evidence that higher levels of progestin from the contraceptive implant were associated with bleeding side effects experienced by women in this study. Pharmacologic variation may influence the side effects women experience with a variety of hormonal contraceptive methods, in turn affecting patient satisfaction and discontinuation rates. PMID: 31503152 [PubMed - as supplied by publisher]
ConclusionSCEM followed by SC appears to be an effective treatment option for CSP. The method seems to be safe in short-term follow-up. However, complications were observed in long-term follow-up. Therefore, patients should be informed about the risk of complications interfering with future fertility, such as intrauterine adhesions and/or amenorrhea.
ConclusionHT associated with post-partum AKF is relatively frequent, secondary to HELLP syndrome and tubular necrosis. The prognosis depends on the early diagnosis and treatment and on the preventive measures during the pregnancy (self-measurement of blood pressure monitoring or ambulatory measurement of blood pressure, screening for proteinuria and uric acid analysis).
This study aims to evaluate the efficacy of the combination of bipolar radiofrequency impedance-controlled endometrial ablation (NovaSure®) and levonorgestrel intrauterine system (LNG-IUS, Mirena) placement in comparison with NovaSure® endometrial ablation alone in patients with abnormal uterine bleeding (AUB).DesignA propensity-score-matching study.SettingBeijing Tiantan Hospital, Capital Medical University, Beijing, China.PatientsA retrospective study was conducted on 246 patients with AUB, who underwent NovaSure® endometrial ablation with (NovaSure®+LNG-IUS) or without (NovaSure® group) LNG-IUS betwe...