Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa

Conclusion: This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. PMID: 31823595 [PubMed - as supplied by publisher]
Source: Journal of Psychiatry and Neuroscience - Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

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Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 45-year-old man is evaluated for anorexia, dizziness, and weakness. He was discharged from the hospital 5 days ago after transsphenoidal pituitary surgery for a pituitary macroadenoma abutting the optic chiasm. His postope rative course was uneventful, and his postoperative hormone evaluation […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Nephrology Source Type: blogs
ConclusionsScurvy is caused by vitamin C deficiency. Cutaneous bleeding, mucosal bleeding, and anemia represent typical manifestations of the disease. These symptoms are directly connected to ascorbic acid involvement in collagen biosynthesis. Some radiographic findings can be useful for the diagnosis. Treatment aims to normalize serum levels of vitamin C in order to counteract the deprivation symptoms. The present case report demonstrates that scurvy may sporadically occur in pediatric patients, even in individuals with no predisposing medical conditions and/or potential risk factors.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractCholesteryl pullulan (CHP) is a novel antigen delivery system. CHP and New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen complexes (CHP-NY-ESO-1) present multiple epitope peptides to the MHC class I and II pathways. Adjuvants are essential for cancer vaccines. MIS416 is a non-toxic microparticle that activates immunity via the nucleotide-binding oligomerization domain 2 (NOD2) and TLR9 pathways. However, no reports have explored MIS416 as a cancer vaccine adjuvant. We conducted a first-in-human clinical trial of CHP-NY-ESO-1 with MIS416 in patients with NY-ESO-1-expressing refractory solid tumors. CH...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
This report makes no claim to superiority of FBT compared to other therapies in addressing these broader concerns nor does it add interventions to augment the current manual to improve FBT.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Date: Wednesday, 02 19, 2020; Speaker: Philip S. Mehler, MD, Founder and Executive Medical Director, ACUTE Center for Eating Disorders, Denver Health , and Glassman Professor of Medicine, University of Colorado School of ; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
AbstractObjectiveTo evaluate the effect of Chinese herbal medicine formula, modified Liujunzi Decoction ( 六君子汤, MLJZT), for anorexia, utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer (NSCLC).MethodsThe study adopted a propensity score-matched design based on a prospective database. From February 2016 to September 2017, patients with advanced NSCLC that received both cisplatin-based chemotherapy and MLJZT (IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone (control group). Changes in anorexia and ...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
We describe a unique case of hyperphosphatemia associated with a very high bone turnover rate in a 51-year-old postmenopausal woman with undiagnosed anorexia nervosa (AN) who presented with a low-trauma hip fracture. In view of her severely malnourished state, she was not fit for surgery. She was treated according to a refeeding protocol that mandated bed rest. Contrary to expectation, she developed sustained hyperphosphatemia and borderline hypercalcemia. Bone remodelling markers, both resorption and formation, were markedly elevated. Parathyroid hormone (PTH) was low-normal at 1.7  pmol/L, C-terminal fibroblast grow...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
For more information go tohttps://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 2/19/2020 12:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
When treating antibiotic-resistant infections, injecting patients with other people ’s excrement can be highly effective. Could it be the answer to dementia, anorexia and obesity too?The man and woman are wearing blue hospital gowns and clear face shields. Dr James Sones and Dr Indu Srinivasan are in a room in the Division of Digestive Diseases at the University of Mississippi Medical Center in Jackson. They are about to create something that has spread through medicine like, well, a shitstorm.Sones takes a brown gloopy material and spoons it into what looks like a regular kitchen blender. The camera zooms in to a la...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health & wellbeing Digestive disorders Microbiology Life and style Science Society Source Type: news
This pilot study adapted family-based treatment (FBT) for youth with potentially prodromal anorexia nervosa (AN). Fifty-nine youth with clinically significant AN symptom constellations, but who never met full Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) (DSM-IV) criteria for AN, were enrolled in a partially randomized preference design study. Participants were offered randomization to FBT or supportive psychotherapy (SPT); those who declined to be randomized because of a strong treatment preference were entered into a parallel, non-randomized self-selected intervention study. Without accessing...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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