Imbalance between Th17 and regulatory T cells in patients with systemic lupus erythematosus combined EBV/CMV viraemia.

CONCLUSIONS: The monitoring of lymphocytes and CD4+ T cell subsets, especially Th17 and Treg cells, may be helpful for identifying EBV/CMV infection in SLE patients. The results presented here suggest that, in addition to Treg, Th17 may also be crucial in the Th17/Treg imbalance seen in patients with SLE combined with EBV and/or CMV viraemia. A decrease in Th17 cells may be an important feature of EBV and/or CMV infection in SLE. Appropriate immunomodulatory therapy for CD4+ T cell subsets based on antiviral therapy may be beneficial for SLE patients with EBV and/or CMV viraemia. PMID: 31820723 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research