A case of Ewing-like sarcoma showing trilaminar differentiation after treatment

Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Mia C. Weiss, Marta Batus, Rahul B. Jadhav, Manuel Utset, Cristina O'Donoghue, Ira MillerAbstractHere we present a case of a 56 year old male with an Ewing-like bilateral retroperitoneal sarcoma with evidence of a EWSR1-POU5F1 fusion gene. Biopsy showed a high grade round cell sarcoma expressing strong membranous CD99 antigen. The tumor shrank considerably after extensive neoadjuvant chemo-radiation therapy. The resected specimens showed complete regression of the malignant component, with the residual tumor resembling ganglioglioma as well as of differentiated tumors of endoderm and mesoderm. While ganglioneuromatous differentiation of Ewing sarcoma has previously been reported, the other elements are a novel finding and may be attributed to the uncommon fusion transcript identified in this case and to the effect of therapy.
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research

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AbstractWhile sarcomas account for approximately 1% of malignant tumors of adults, they are particularly more common in children and adolescents affected by cancer. In contrast to malignancies that occur in later stages of life, childhood tumors, including sarcoma, are characterized by a striking paucity of somatic mutations. However, entity-defining fusion oncogenes acting as the main oncogenic driver mutations are frequently found in pediatric bone and soft-tissue sarcomas such as Ewing sarcoma (EWSR1-FLI1), alveolar rhabdomyosarcoma (PAX3/7-FOXO1), and synovial sarcoma (SS18-SSX1/2/4). Since strong oncogene-dependency h...
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Source: Head and Neck Pathology - Category: Pathology Source Type: research
Contributors : Naofumi Asano ; Hideyuki Takeshima ; Satoshi Yamashita ; Eisuke Kobayashi ; Akira Kawai ; Tadashi Kondo ; Toshikazu UshijimaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensDNA methylation in osteosarcoma and Ewing sarcoma
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
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