DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1 [Neuroscience]

Loss-of-function mutations in DJ-1 are associated with autosomal recessive early onset Parkinson’s disease (PD), yet the underlying pathogenic mechanism remains elusive. Here we demonstrate that DJ-1 localized to the mitochondria-associated membrane (MAM) both in vitro and in vivo. In fact, DJ-1 physically interacts with and is an essential component of...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Yi Liu, Xiaopin Ma, Hisashi Fujioka, Jun Liu, Shengdi Chen, Xiongwei Zhu Tags: Biological Sciences Source Type: research