Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake [Medical Sciences]

Binge drinking and chronic exposure to ethanol contribute to alcoholic liver diseases (ALDs). A potential link between ALDs and circadian disruption has been observed, though how different patterns of alcohol consumption differentially impact hepatic circadian metabolism remains virtually unexplored. Using acute versus chronic ethanol feeding, we reveal differential reprogramming of...

Source: Proceedings of the National Academy of Sciences - December 9, 2019 Category: Science Authors: Jonathan Gaucher, Kenichiro Kinouchi, Nicholas Ceglia, Emilie Montellier, Shahaf Peleg, Carolina Magdalen Greco, Andreas Schmidt, Ignasi Forne, Selma Masri, Pierre Baldi, Axel Imhof, Paolo Sassone-Corsi Tags: Biological Sciences Source Type: research