Progression of Interstitial Lung Disease in Systemic Sclerosis: The Importance of Pneumoproteins Krebs von den Lungen 6 and CCL18

ConclusionIn a rigorously conducted clinical trial for SSc ‐related ILD, KL‐6 and CCL18 levels correlated with ILD severity and declined with immunosuppression. Patients with higher baseline KL‐6 and CCL18 levels were more likely to experience disease progression despite treatment. KL‐6 and CCL18 levels could be used to identify patients with a prog ressive ILD phenotype who may benefit from a more aggressive initial treatment approach.

Source: Arthritis and Rheumatology - November 27, 2019 Category: Rheumatology Authors: Elizabeth R. Volkmann, Donald P. Tashkin, Masataka Kuwana, Ning Li, Michael D. Roth, Julio Charles, Faye N. Hant, Galina S. Bogatkevich, Tanjina Akter, Grace Kim, Jonathan Goldin, Dinesh Khanna, Philip J. Clements, Daniel E. Furst, Robert M. Tags: Original Article Source Type: research