Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Publication date: 1 January 2020Source: Colloids and Surfaces B: Biointerfaces, Volume 185Author(s): Fazlurrahman Khan, Dung Thuy Nguyen Pham, Sandra Folarin Oloketuyi, Panchanathan Manivasagan, Junghwan Oh, Young-Mog KimAbstractBiofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and it...
Hello all, I have a question I'm not sure about the answer or where to post on the forum. Patient is going to have knee replacement and has penicillin allergy, although he is stable on cephalexin. What would be the best antibiotic to use peri-operatively? Choice of antibiotics: cefazolin, vancomycin, clindamycin. I was thinking cefazolin because it's a 1st gen like cephalexin, but a friend argued for vancomycin. What do you guys think?
CONCLUSIONS: A positive medical history, especially of mothers and cEo, seem to be predictive in screening for the onset of allergic diseases. PMID: 31951684 [PubMed - in process]
When I first saw Jea-Hyoun, in a medical meet-cute straight out of a romantic comedy, she was being evaluated for thyroid cancer. I was an allergy/immunology fellow harried by a pile of paperwork. She was a patient, in the same building where she saw patients of her own as a psychiatry and family practice resident, […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Hey guys, had a patient with sulfa/sulfonamides allergy who I dispensed Meloxicam. Pt states that sulfa is in meloxicam structure so she is having anaphylactic reaction due to taking Meloxicam 8 hours earlier I checked Lexicom/Clinical pharmacology, and I just cant find it being as contraindication... Of course, pt is threatening to go to a hospital/sue/etc... Am I overlooking it as a contraindication? Can you guys double check me?
This study aimed to identify the phenotype and immunologic findings in Korean children with barley allergy. METHODS: Forty-two participants with a history of ingesting barley who underwent serum specific immunoglobulin E to barley (barley-sIgE) assay at the Department of Pediatrics in Ajou Medical Center were enrolled through a retrospective analysis of medical records from March 2008 to February 2018. The demographic characteristics, symptoms, and immunologic parameters of the patients were assessed. RESULTS: Twenty subjects presented with clinical barley allergy (B-allergic group), and 22 were atopic controls w...
CONCLUSIONS: All patients with a suspected contact allergy should receive a guideline-based patch test at an early stage. Targeted patch testing identifies clinically relevant allergens and provides suggestions for further systematic investigations. PMID: 31950209 [PubMed - as supplied by publisher]
This article reviews the clinical applications for macrolide and doxycycline use in CRS, considerations for dosing and duration of treatment, and important side effects and drug interactions ass ociated with these medications.
This article reviews primary immunodeficiencies contributing to chronic rhinosinusitis, including a proposed diagnostic work-up and the evidence for treatment in this unique population.
Establishment of the gastrointestinal microbiota during infancy affects immune system development and oral tolerance induction. Perturbations in the microbiome during this period can contribute to development of immune-mediated diseases. We monitored microbiota maturation and associations with subsequent development of allergies in infants and children.