Comparative evaluation of biphasic insulin with metformin and triple oral hypoglycemic agents (OHA) in type 2 diabetes patients

Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Sirajudeen Shaik Alavudeen, Moteb Khobrani, C.K. Dhanapal, Javid Iqbal Mir, Sultan Mohammed Alshahrani, Noohu Abdullah Khan, Abdulaziz Alhossan
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research

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TYPE 2 diabetes is a common condition yet many people in the UK will not realise they have it because the symptoms do not necessarily make you feel unwell. Symptoms are caused by consistently high blood sugar levels, and, overtime, this can affect different parts of the body, including the shoulder.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aimed to design a simple surrogate marker (i.e., predictor) of the minimal model glucose effectiveness (SG), namely calculated SG (CSG), from a short insulin-modified intravenous glucose tolerance test (IM-IVGTT), and then to apply it to study women with previous gestational diabetes mellitus (pGDM). METHODS: CSG was designed using the stepwise model selection approach on a population of subjects (n=181) ranging from normal tolerance to type 2 diabetes mellitus (T2DM). CSG was then tested on a population of women with pGDM (n=57). Each subject underwent a 3-hour IM-IVGTT; women with pGDM were observed early ...
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
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Source: Endocrine Research - Category: Endocrinology Authors: Source Type: research
We reported a significant increase of ghrelin epsilon-cells in the pancreas and basal serum after Sleeve gastrectomy versus the control groups. The epsilon cellular increment was related to neogenesis, as the neurogenin-3 marker revealed. The Roux-en Y Gastric Bypass showed neither epsilon cell increase nor basal serum changes in ghrelin release. As a conclusion, we reported that the severe suppression of the fundus gastric produced the recovery of ghrelin released by the epsilon cells, which was indicative of an ontogenic embryonic pancreatic function. PMID: 31951010 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
TYPE 2 diabetes symptoms tend to develop gradually so many people in the UK will be living with the condition without realising it. Symptoms arise as a result of consistently high blood sugar levels and there are a number of signs in your mouth that can indicate uncontrolled blood sugar levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Contributors : Simon Dankel ; Regine Asen ; Laurence Dyer ; Divya PriyankaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensObesity, and visceral adiposity in particular, increases the risk of common metabolic diseases, including type 2 diabetes, cardiovascular disease, and several forms of cancer. However, the molecular mechanisms responsible for regional fat storage remain poorly characterized, preventing therapeutic innovation. We here applied a systematic genome-wide screen and translational approach, and discovered a novel role for the adipocyte-expressed neutral amino acid transpo...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Simon Dankel ; Regine AsenSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioObesity, and visceral adiposity in particular, increases the risk of common metabolic diseases, including type 2 diabetes, cardiovascular disease, and several forms of cancer. However, the molecular mechanisms responsible for regional fat storage remain poorly characterized, preventing therapeutic innovation. We here applied a systematic genome-wide screen and translational approach, and discovered a novel role for the adipocyte-expressed neutral amino acid transporter SLC7A10/ASC-1 in the regulati...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
Source: Critical Reviews in Food Science and Nutrition - Category: Nutrition Authors: Source Type: research
We describe evidence for substance use as a risk factor for new-onset diabetes, prevalence of use in people with diabetes, evidence linking substance use with diabetes-related health outcomes, and evidence on the management of these co-occurring conditions.
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
ConclusionSilent myocardial ischemia is highly prevalent at about one in four asymptomatic diabetic patients. An increased CIMT can be a surrogate marker of higher coronary risk amongst these asymptomatic diabetics.
Source: Indian Heart Journal - Category: Cardiology Source Type: research
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