Cochrane China Network working groups meeting - November 2019

Cochrane China Network working groups had an informal meeting included in the 13th China Health Technology Assessment Forum, hosted by Prof Yingyao Chen (from Fudan University) on 17th November.Eight Cochrane China Network working groups reported their work on Cochrane and some achievements in health technology assessment Cochrane. Prof Jianping Liu (Beijing University of Chinese medicine) gave the opening session, and introduced Cochrane China network and the whole session.Prof Shiyao Chen, from Zhongshan hospital affiliated to Fudan University, talked about “The clinical decision on screening helicobacter pylori for gastric cancer, when combined with the Cochrane evidence, how to make decision”.Prof Yaolong Chen, from Lanzhou University andCochrane China Network GRADE and guidelines Working Group, introduced the process of publishing the RIGHT, the Standards of reporting guidance for clinical guideline.Prof Yan Hu, from Fudan University and Cochrane China Network Nursing Working Group, presented the model and practice on clinical evidence and translation, specific in the field of nursing and quality study.Prof Yinghui Jin, from Center for evidence-based and translational medicine, Wuhan university, presented the important aspects we should take care of, especially the health economics, during the process of developing guideline and conduct the guideline.Prof Jianping Liu, from Beijing University of Chinese medicine and Cochrane China Network Traditional Chinese ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Conclusions: Gastric cancer has the fourth highest incidence of various cancers worldwide and is ranked second as a cause of cancer-related death. It exists from the antiquity and a lot of hypotheses have been developed about its etiology during the centuries, influencing its therapy. During the 20th century, thanks to the scientific and technological progresses the causes of the cancer have been discovered and the role of the bacterium Helicobacter pylori has been demonstrated, and new perspective research are currently trying to investigate the role of other microorganisms in gastric physiopathology, as well as its possi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Annibale B, Esposito G, Lahner E Abstract SUMMARYIntroduction: Atrophic gastritis (AG) is a complex syndrome which arise as consequence of H. pylori infection or in the context of gastric autoimmunity. It often deserves a benign course, but may lead to potentially life-threatening complications: cancer and anaemia. This review aims to address traditional and innovative knowledge on this often under-diagnosed disorder.Areas covered: This review covers clinical presentation, risk factors, diagnosis and management of AG and provides an updated resource for clinicians to get insight in this challenging disorde...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
This study investigated the molecular targets of the component herbs of QLSP in preventing precancerous lesions based on network pharmacology. Network pharmacology analysis revealed that the 6 herbs regulated multiple CAG-related genes, among which the most important were cancer-related pathway (apoptosis, p53, and VEGF) and epithelial cell signaling in Helicobacter pylori infection. Further animal experiments showed that the expression of survivin and p53 in precancerous lesions of CAG rats was significantly increased which was suppressed by QLSP. Moreover, telomerase activity was inhibited in precancerous lesions of CAG ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Source: Gastroenterology - Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activity Source Type: research
ConclusionThe age-standardized prevalence of H. pylori infection in Taiwan was 21.8% in asymptomatic adults in 2018. The Vstrip® HpSA had equivalent performance as the ImmunoCard STAT!® HpSA, and can be used in future mass screening of H. pylori infection for gastric cancer prevention.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Forty-five years have passed since Correa et  al1 proposed their hypothesis on the histopathological cascade leading to gastric adenocarcinoma claiming that gastric cancer usually resulted from chronic gastritis, subsequently leading to gland loss or atrophy, intestinal metaplasia, dysplasia, and eventually invasive cancer. The most common ri sk factor for gastritis soon revealed to be the colonization with Helicobacter pylori.2 Most infections occur during childhood and remain for life. They are almost invariably associated with chronic gastritis, which may eventually lead to a loss of mucosal glands.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Mentoring, Education, and Training Corner Source Type: research
meyer Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin poses an attractive target for pathogens to manipulate a given host cell to their own benefit. One of the pathogens following this strategy is Helicobacter pylori, which can cause a variety of gastric diseases and has been shown to be the major risk factor for the onset of gastric cancer. During infection of gastric epithelial cells, H. pylori hijacks the cellular kinase signaling pathways, leading to the disruption of key cell fun...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Macrophages have a major role in infectious and inflammatory diseases, and the available data suggest that Helicobacter pylori persistence can be explained in part by the failure of the bacterium to be killed by professional phagocytes. Macrophages are cells ready to kill the engulfed pathogen, through oxygen-dependent and -independent mechanisms; however, their killing potential can be further augmented by the intervention of T helper (Th) cells upon the specific recognition of human leukocyte antigen (HLA)-II–peptide complexes on the surface of the phagocytic cells. As it pertains to H. pylori, the bacterium is eng...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: The age-standardized prevalence of H. pylori infection in Taiwan was 21.8% in asymptomatic adults in 2018. The Vstrip® HpSA had equivalent performance as the ImmunoCard STAT!® HpSA, and can be used in future mass screening of H. pylori infection for gastric cancer prevention. PMID: 31926791 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
NICE will not approve volanesorsen on the NHS Related items fromOnMedica NICE recommends Herceptin for gastric cancer H. pylori eradication linked to reduced risk of gastric cancer Use of DPP-4 inhibitors associated with increased risk of IBD Aspirin could also treat cancer, research suggests Antivirals cut liver cancer risk after hepatitis C
Source: OnMedica Latest News - Category: UK Health Source Type: news
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