Is endometriosis more common and more severe than it was 30 years ago?

ConclusionAs with all human studies, population sampling and study design matter. Heterogeneity of inclusion and diagnostic criteria and selection bias overwhelmingly account for variability in endometriosis prevalence estimated across the literature. Thus, it is difficult to conclude if the lack of observed change in frequency and distributions of endometriosis over the past 30 years is valid.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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We present the case of a pregnant woman admitted for sudden and severe abdominal pain at 34 weeks gestation. Her previous medical history included endometriosis suspected by clinical symptoms and ultrasound. During cesarean section, performed by sustained fetal bradycardia, a large volume hemoperitoneum and multiple hemorrhagic foci in the posterior uterine wall were detected. Although rare, spontaneous hemoperitoneum may occur in pregnancy, especially in women with endometriosis. Thus, a prompt suspicion and expedite intervention are needed to improve maternal and fetal outcomes. PMID: 31703187 [PubMed - in process]
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Purpose of review To investigate the JZE alterations in gynecological and obstetrical disorders and impact on diagnosis, prognosis and treatment. Recent findings JZE was found to be significantly extended in patients with endometriosis, leading to the conclusion that endometriosis is a primary disease of the uterus, much like adenomyosis. Statistical correlation was then demonstrated between the severity of endometriosis and the depth of the adenomyosis infiltrates, hence the thickening of the JZE. Stem cells, predominantly found in the JZE were also found in histological sections of leiomyoma, suggested to be the ori...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: WOMEN'S HEALTH: Edited by Joseph Aquilina Source Type: research
Conclusion Dyspareunia and acyclic pain were independent factors of correlation with high scores in the EHP-30 questionnaire, reflecting a worse quality of life.Resumo Objetivo Avaliar a exist ência de associação entre os achados ultrassonográficos e os fatores epidemiológicos e clínicos com os resultados obtidos no questionário EHP-30 em mulheres com diagnóstico de endometriose ovariana. Métodos Realizou-se um estudo observacional transversal entre julho de 2012 emaio de 2015, no qual as pacientes com dor pélvica crônica com imagem sugestiva de end...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Endometriosis is a common cause of chronic pelvic pain, dysmenorrhea and infertility. Although 6 –10% of women of child bearing age are affected by the disease, and even more in the group of patients with fertility problems, diagnosis is often delayed and treatment can be challenging. Depending on the complaints, extent of disease and the goals of treatment (fertility treatment, pain reducti on, …), both medical and surgical options are available for the management of this pathology and often a  multidisciplinary approach will be necessary. Although diagnostic laparoscopy with histologic confirmation...
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
ConclusionTraditionally only pathologies of the uterus and ovaries are assessed during a routine pelvic ultrasound. Here we demonstrate that the routine ultrasound examination can easily be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments to evaluate structural mobility and to look for deep infiltrating endometriotic nodules, so women suffering from deep infiltrating endometriosis can benefit from a pre-operative diagnosis and subsequently a single, well-planned procedure in the hands of a well-prepared team.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the develop...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we aimed to determine the expression ofH19 and ACTA2 in endometrial tissues of women with endometriosis. Two groups of 23 infertile women with endometriosis and 23 matched infertile women without endometriosis were investigated. Primary cultured cells of endometrial tissues were analyzed using RT-PCR and western blotting (WB) to determine expression ofH19 and ACTA2. 5-Ethyl-2 ′-deoxyuridine, CCK8 and Transwell assays were used to study the functions ofH19 and ACTA2. Human embryonic kidney 293 cells were used for luciferase assays to study miR-216a-5p binding sites withH19 andACTA2. We found thatH19 and...
Source: Molecular Human Reproduction - Category: Molecular Biology Source Type: research
The modulation of endometriosis by lncRNA MALAT1 via NF-κB/iNOS. Eur Rev Med Pharmacol Sci. 2019 May;23(10):4073-4080 Authors: Yu J, Chen LH, Zhang B, Zheng QM Abstract OBJECTIVE: Endometriosis (Ems) is one benign disorder that frequently leads to chronic pelvic pain, dysmenorrhea or even infertility. Featured as the ectopic growth of active endometrial tissues on tissues beyond the muscular layer, Ems has complicated pathogenesis mechanisms that are not fully illustrated. Long non-coding (lnc) RNA MALAT1 participates in various biological activities, including cell growth, proliferation, apoptos...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 27 May 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Aurélie Comptour, Bruno Pereira, Céline Lambert, Pauline Chauvet, Anne-Sophie Gremeau, Jean-Luc Pouly, Michel Canis, Nicolas BourdelABSTRACTStudy objectiveTo investigate predictive factors for change in quality of life (QoL) between pre and post-operative periods in patients with endometriosisDesignProspective and multicenter cohort studySetting5 districts including a tertiary referral center, private and general public hospitalsPatient981 patients, aged 15-50 years, underwent laparoscopic treatment (prefe...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
(Abstracted from J Minim Invasive Gynecol 2019;26:71–77) The primary sequelae of endometriosis are infertility and chronic pelvic pain (CPP). Nearly 40% of women with endometriosis are infertile, and 71% to 87% have CPP.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: OPERATIVE GYNECOLOGY Source Type: research
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