Physical activity rates in children and adolescents with autism spectrum disorder compared to the general population

The objective of this study was to compare the reported frequency of physical activity and covariates in a large sample of children with ASD with children of similar age from the general population. The sample with ASD was derived from the Autism Treatment Network Registry Call Back Assessment (n = 611), and the general population data were derived from the National Survey of Children’s Health (NSCH) (n = 71,811). In addition, demographic, child, and family (parent) factors were examined in relation to frequency of recent physical activity in children with ASD. Among males in the 6−11 year-old age group, those with ASD participated in physical activity less often (p
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research

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Publication date: Available online 25 January 2020Source: NeuroImage: ClinicalAuthor(s): Laurie-Anne Sapey-Triomphe, Bart Boets, Lien Van Eylen, Ilse Noens, Stefan Sunaert, Jean Steyaert, Johan WagemansAbstractObject recognition relies on a hierarchically organized ventral visual stream, with both bottom-up and top-down processes. Here, we aimed at investigating the neural underpinnings of perceptual organization along the ventral visual stream in Autism Spectrum Disorders (ASD), and at determining whether this would be associated with decreased top-down processing in ASD. Nineteen typically developing (TD) adolescents and...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Translational Psychiatry, Published online: 27 January 2020; doi:10.1038/s41398-020-0692-2Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
Publication date: Available online 25 January 2020Source: NeuroImageAuthor(s): Thomas A.W. Bolton, Lorena Freitas, Delphine Jochaut, Anne-Lise Giraud, Dimitri Van De VilleAbstractNaturalistic movie paradigms are exquisitely dynamic by nature, yet dedicated analytical methods typically remain static. Here, we deployed a dynamic inter-subject functional correlation (ISFC) analysis to study movie-driven functional brain changes in a population of male young adults diagnosed with autism spectrum disorder (ASD). We took inspiration from the resting-state research field in generating a set of whole-brain ISFC states expressed by...
Source: NeuroImage - Category: Neuroscience Source Type: research
(University of Cambridge) Bumetanide -- a prescription drug for oedema (the build-up of fluid in the body) -- improves some of the symptoms in young children with autism spectrum disorders and has no significant side effects, according to a new study from researchers in China and the UK.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionThe DRA provides crucial information about levels of and desire for autonomy that can be used to promote participation of adolescents with ASD in setting their own goals for independent living.
Source: Journal of Adolescence - Category: Child Development Source Type: research
ConclusionsPractitioners should consider use of less restrictive or intrusive interventions to promote food acceptance and the use of larger sets of foods, modified to include fewer foods in the case of poor response to intervention.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
This study explored the relationship between the two disorders by collecting extensively validated measures of autistic trait burden (Social Responsive Scale, Second Edition) and schizoid PD affectation (Diagnostic Interview for Genetic Studies) from clinically ascertained verbal males with and without autism ages 12 to 25 years (N = 72) via parent, teacher, and self-report. Although only a small minority of adolescents with ASD met full diagnostic criteria for schizoid PD, participants with ASD endorsed a continuous distribution of schizoid PD traits that reflected a pronounced pathological shift in comparison with those ...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n = 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to integrate de novo and case-control rare variation, we identify 102 risk genes at a false discovery rate of 0.1 or less. Of these genes, 49 show higher frequencies of disruptive de novo variants in individuals ascertained to have severe neurodevelopmental delay, whereas 53 show higher frequencies in individuals ascertained to have ASD; comparing ASD cases with mutations in these groups reveals phenotypic differences. Expressed early in brain devel...
Source: Cell - Category: Cytology Source Type: research
In conclusion, the analyses on simulated and real EEG data demonstrate that staNMF can be used to characterize dynamic functional networks, making it a promising tool for investigating disorders using resting-state EEG.
Source: Neurocomputing - Category: Neuroscience Source Type: research
Abstract Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans. Accordingly, in utero exposure to VPA is a validated and biologically relevant animal model of ASD. The majority of individuals with ASD exhibit some degree of auditory dysfunction, ranging from deafness to hypersensitivity. Animals exposed to VPA in utero have abnormal tonotopic maps and responses in the cerebral cortex and hyperactivation, hypoplasia, abnormal neuronal morphology and reduced calcium binding protein expression throughout the auditory brainstem nucle...
Source: Experimental Brain Research - Category: Neuroscience Authors: Tags: Exp Brain Res Source Type: research
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