Baseline global longitudinal strain by computed tomography is associated with post transcatheter aortic valve replacement outcomes

Computed tomography angiography derived global longitudinal strain (CTA-GLS) has been shown to be feasible, however its prognostic value remains unclear in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). We evaluated the association of baseline CTA-GLS with outcomes including all-cause mortality and composite endpoint of death and heart failure hospitalization in 223 patients treated with TAVR. Patients with normal LVEF but reduced CTA-GLS had similar event rate to those with impaired LVEF, and higher than those with normal LVEF and preserved CTA-GLS. Baseline CTA-GLS assessment might be helpful in patients with difficult echocardiographic images undergoing TAVR evaluation.
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Source Type: research

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Balloon aortic valvuloplasty (BAV) is indicated in patients with acute decompensated heart failure or cardiogenic shock secondary to severe aortic stenosis,1 either as palliative therapy for patients who are not candidates for valve replacement,2 or as a bridge to transcatheter (TAVR) or surgical aortic valve replacement (SAVR).1,3 Given the high morbidity and mortality associated with BAV, especially because it is performed not infrequently in critically ill patients, it is important to understand the effect of hospital procedural volume on outcomes following BAV.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
AbstractPurposeThe SERVE-HF study revealed no benefit of adaptive servoventilation (ASV) versus guideline-based medical treatment in patients with symptomatic heart failure, an ejection fraction (EF) ≤45% and a predominance of central events (apnoea-hypopnea Index [AHI]>  15/h). Because both all-cause and cardiovascular mortality were higher in the ASV group, an EF ≤ 45% in combination with AHI 15/h, central apnoea-hyponoea index [CAHI/AHI]>  50% and central apnoea index [CAI]>  10/h were subsequently listed as contraindications for ASV. The intention of our study was to analyse the clinical rel...
Source: Somnologie - Schlafforschung und Schlafmedizin - Category: Sleep Medicine Source Type: research
Conditions:   Aortic Valve Stenosis;   Heart Failure;   Inotropic Agents;   Safety Issues;   Effect of Drug;   Cardiac Event;   Transcatheter Aortic Valve Replacement Interventions:   Drug: Levosimendan;   Other: Placebo Sponsors:   China National Center for Cardiovascular Diseases;   China International Medical Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
FRIDAY, Oct. 2, 2020 -- For patients with symptomatic severe aortic stenosis, deferred aortic valve replacement (AVR) is associated with an increased risk for hospitalization for valve-related symptoms or worsening heart failure, according to a...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Mild aortic stenosis (AS) and aortic sclerosis are associated with increased mortality in the general population, which may be mediated by their reflection of underlying inflammation and obesity, both risk factors for HFpEF.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 083 Source Type: research
We describe a case of acute heart failure secondary to aortic arch stenosis resulting from subacute type A aortic dissection. Resection of large thickened immobile intimal flap with total aortic arch replacement was successful, and cardiac function improved.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
There has been a rapid dissemination of transcatheter aortic valve implantation (TAVI) since it was first approved in the United States (U.S.) in 2011. As the procedure continues to evolve and improve as a modality for treatment of patients with severe symptomatic aortic stenosis, resource utilization in performing TAVI has attained an important focus.1 The Hospital Readmission Reduction program, established in 2012 by the Centers for Medicare and Medicaid Services, penalizes hospitals with higher than expected risk-standardized 30-day readmissions for medical conditions such as heart failure.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
AbstractBackgroundTissue-tracking mitral annular displacement (TMAD) by speckle-tracking echocardiography provides rapid and simple assessment of left ventricular (LV) longitudinal deformation. The purpose of this study was to evaluate the value of TMAD for the assessment of LV longitudinal deformation in patients with severe AS and preserved LV ejection fraction (LVEF).MethodsWe studied 44 patients with severe AS  preserved and LVEF in whom TMAD was assessed. Using TMAD analysis software, the base-to-apex displacement of automatically defined mid-point of mitral annular line in four-chamber view was quickly assessed,...
Source: Journal of Echocardiography - Category: Cardiology Source Type: research
CONCLUSIONS: The present study has demonstrated very good mid-term outcomes of TAVI with the J-Valve system in the treatment of patients with either AS or AI, suggesting the J-Valve system is a compromising alternative therapy in high-risk patients. PMID: 32980330 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
AbstractAn 86 ‐year‐old man affected by severe aortic stenosis (AS) was referred to our institution owing to decompensated heart failure. Three months before, the patient was scheduled for transcatheter aortic valve implantation (TAVI), which was postponed owing to the coronavirus disease 2019 (COVID‐19) ou tbreak. Owing to COVID‐19 suspicion, he underwent nasopharyngeal swab and was temporarily isolated. However, the rapid deterioration of clinical and haemodynamic conditions prompted us to perform balloon aortic valvuloplasty (BAV) as bridge to TAVI. The patient's haemodynamics improved; and the ne xt day, the re...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
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