Photobiomodulation by dual-wavelength low-power laser effects on infected pressure ulcers

AbstractThe aim of this study was to evaluate the effects of photobiomodulation (PBM) by dual-wavelength low-power lasers on the healing and bacterial bioburden of pressure ulcer (PU) models. Twenty-five male Swiss mice were divided into five equal groups. Ischemia reperfusion cycles were employed to cause PU formation by the external application of magnetic plates. Immediately after wounding, a suspension ofPantoea agglomerans was applied at the base of all the wounds of the infected groups, using a calibrated pipette. PBM (simultaneous emission at 660 and 808  nm, 142.8 J/cm2, in continuous wave emission mode) was applied to the PUs for 14 sessions. The animals were euthanized 14  days after PU induction, and their tissues were analyzed for wound contraction and reepithelialization, epidermis thickness, bacterial survival, and IL-1β and IL-10 mRNA level evaluations. The PU areas appeared larger in the mice from the infected groups than in those in the laser group 4 days a fter PU induction and presented incomplete reepithelialization 14 days after PU induction. However, the PBM accelerated the wound healing in the infected + laser group compared with the infected group 11 and 14 days following the PU induction. The infected and irradiated PUs exhibited a thinner ne o-epidermis than those in the infected group, and the bacterial survival decreased in the laser group; the relative expression IL-1β mRNA levels demonstrated an increasing ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research

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Publication date: Available online 23 January 2020Source: The American Journal of SurgeryAuthor(s): Jeremy A. Warren, Michael Love, William S. Cobb, Lucas R. Beffa, Francisco J. Couto, B.H. Hancock, D. Morrow, Joseph A. Ewing, Alfredo M. CarbonellAbstractBackgroundProsthetic mesh infection (PMI) is a challenging complication of ventral hernia repair (VHR). The sparsity of data leaves only experience and judgment to guide surgical decision-making.MethodsRetrospective review of patients diagnosed with PMI. Subsequent abdominal operation (SAO) constitutes any intraabdominal operation occurring after the index hernia repair pr...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
CONCLUSIONS: To the best of the authors' knowledge, this is the first reported case in which an instance of pediatric foot degloving is presented with serial debridement, NPWT, and biological dressings, resulting in no additional plastic surgical techniques needed to provide return to functional outcome. PMID: 31876514 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
Rationale: Tension-free repair of inguinal hernia with prosthetic materials in adults has become a routine surgical procedure. However, serious complications may arise such as mesh displacement, infection, and even enterocutaneous fistula (EF). The management of chronic mesh infection (CMI) complicated by an EF is very challenging. A simple treatment of infected mesh removal and negative pressure wound therapy (NPWT) may cure the patients with EF with CMI. Patient concerns: A 75-year-old male patient underwent tension-free treatment for a bilateral inguinal hernia at a county hospital 10 years ago. Three months before...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Pressure ulcers are highly prevalent among adult and elderly patients where risk factors vary. In addition to guidelines to the conventional treatment, some auxiliary therapies such as photobiomodulation have shown promising results in wound healing. In this systematic review, only 5 papers were selected according to the eligibility criteria of this research. It was observed that PBMT red wavelength, similar to standard care, promoted tissue repair with a reduced lesion area. AbstractEvaluation of photobiomodulation therapy (PBMT) in the treatment of pressure ulcers in adults and the elderly. Systematic review, based on th...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research
Abstract In our previous study, we proposed an animal model in which pressure ulcer-like dermal lesions can be produced by denervation of the sciatic nerve and application of a pressure load to rat heel skin. In the present study, we divided these animals into non-treated and pressure loading groups, and initiated hindlimb unloading (depressurization) by tail suspension at 1, 3, 5, 7, and 14 days after inflicting lesions (1-14d pressurization groups). Chronological changes in heel lesions were examined morphologically in all treatment groups after 1, 3, 7, 14, 28, and 40 days. Open dermal lesions were formed by 14...
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Acta Histochem Source Type: research
AbstractEvaluation of photobiomodulation therapy (PBMT) in the treatment of pressure ulcers in adults and the elderly. Method: Systematic review, based on the recommendations of the Handbook, proposed by Cochrane. The search was carried out in databases, records of randomized clinical trials, list of references cited in the selected articles, as well as a manual search in meetings and specialized journals. Results: 1342 studies were identified, 18 were pre ‐selected and 5 were included in this review. Clinical heterogeneity of the participants was observed, in addition to variation in the laser parameters and predominanc...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research
CONCLUSIONS: In these 3 cases, RTM-equipped NPWT and the patient-centric exchanges with the VTS through adherence calls helped promote consistent usage of RTM-equipped NPWT to address the patients' therapeutic needs and increase therapy adherence. PMID: 31483754 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: Use of NPWT with the microadhesive dressing proved successful in the management of this complex and challenging ECF.
Source: Journal of Wound, Ostomy and Continence Nursing - Category: Nursing Tags: Challenges in Practice Source Type: research
We present a generalized IRI model considering external loading, dynamic tissue healing capacity, accumulating mechanical and reperfusion-mediated damages and competing repair processes of saturating nature. Reperfusion depends on strain and strain rate to enhance loading history sensitivity. Tissue-specific ulceration susceptibility is assumed dependent on variable accumulated damage. We study damage evolution under cyclic loading having several strain expulsion profiles and demonstrate load relief history has critical impact on PU progression. Abrupt load removal generally follows existing models representing extreme rep...
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Tags: Biomech Model Mechanobiol Source Type: research
ConclusionGradual postoperative closure of a traumatic abdominal wall hernia with an ostomy in place may result in stomal stenosis. Stomal patency must be carefully evaluated during this process.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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