An Alternative Psychophysical Diagnostic Indicator of the Aging Eye.

Conclusion: Photostress recovery of flicker sensitivity under mesopic conditions is a strong differentiator of aging macular function. This agrees with subject-reported complaints in reduced luminance conditions after exposure to bright lights such as night driving. The qualitative similarity between the aging retina and changes in early AMD suggests that flicker recovery following photostress may be useful as a surrogate endpoint in AMD clinical trials. PMID: 31781372 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research

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Condition:   Age-related Macular Degeneration Intervention:   Procedure: Blood draw and urine collection Sponsor:   Association for Innovation and Biomedical Research on Light and Image Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
BEOVU is a treatment for neovascular (wet) Age-Related Macular Degeneration (AMD).
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
CONCLUSIONS: In this Cochrane Review, no evidence of benefit was found of diverse types of low vision rehabilitation interventions on HRQOL. We found low- and moderate-certainty evidence, respectively, of a small benefit on VRQOL in studies comparing psychological therapies or methods for enhancing vision with active comparators. The type of rehabilitation varied among studies, even within intervention groups, but benefits were detected even if compared to active control groups. Studies were conducted on adults with visual impairment mainly of older age, living in high-income countries and often having AMD. Most of the inc...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSION: The prevalence of choroidal neovascularization in eyes with diabetic retinopathy is very low, with a lower prevalence of age-related macular degeneration. Diabetic choroidopathy plays a significant role in formation of choroidal neovascularization in eyes with diabetic retinopathy. PMID: 31984769 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Ophthalmic Epidemiology - Category: Opthalmology Authors: Source Type: research
Publication date: Available online 23 January 2020Source: Genes &DiseasesAuthor(s): S. Mohana Devi, I. Mahalaxmi, J. Kaavya, V. Chinnkulandhai, V. BalachandarAbstractEpigenetic mechanisms play an important part in the regulation of gene expression and these alterations may induce long-term changes in gene function and metabolism. They have received extensive attention in bridging the gap between environmental exposures and disease development via their influence on gene expression. DNA methylation is the earliest discovered epigenetic alteration. In this review, we try to examine the role of DNA methylation and histone...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
Abstract Purposes: To (i) identify dysregulated circular RNAs (circRNAs) and (ii) elucidate their potential functions in an animal (mouse) model of choroidal neovascularization (CNV), a prominent feature of neovascular age-related macular degeneration (AMD).Methods: Expression profiles for circRNA were identified by microarray analysis. Selected circRNAs were confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Bioinformatic analyses of identified circRNAs were performed to predict (i) circRNA/microRNA interactions and (ii) occurrence of competing endogenous RNA (ceRNA) ne...
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Eye, Published online: 24 January 2020; doi:10.1038/s41433-020-0764-9Ten-year outcomes of antivascular endothelial growth factor therapy in neovascular age-related macular degeneration
Source: Eye - Category: Opthalmology Authors: Source Type: research
Condition:   Neovascular Age Related Macular Degeneration Intervention:   Drug: RTH258/Brolucizumab Sponsor:   Novartis Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Age-Related Macular Degeneration (AMD) | Clinical Trials | Opthalmology | Statistics | Study