Molecules, Vol. 24, Pages 4375: Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa
Molecules, Vol. 24, Pages 4375: Anti-Inflammatory Derivatives with Dual Mechanism of Action from the Metabolomic Screening of Poincianella pluviosa
Molecules doi: 10.3390/molecules24234375
Authors:
Olívia da S. Domingos
Bianca G. V. Alcântara
Mário F. C. Santos
Tatiane C. S. Maiolini
Danielle F. Dias
João L. Baldim
João Henrique G. Lago
Marisi G. Soares
Daniela A. Chagas-Paula
Metabolomics approaches have become fundamental strategies for the analysis of complex mixtures, guiding the isolation of target compounds by focusing on unpublished or promising pharmacological properties. The discovery of novel anti-inflammatory agents is important due to several limitations regarding their potency, efficacy, and adverse effects. Thus, novel anti-inflammatory candidates are essential, aiming to find agents with better mechanisms of action. In this context, extracts from Poincianella pluviosa var. peltophoroides demonstrated significant in vivo anti-inflammatory potential. Thus, metabolomics analysis based on UHPLC-UV-HRFTMS data was performed for the identification of biomarkers with anti-inflammatory properties. Metabolomics-guided chromatographic process led to the isolation of novel compounds 4‴-methoxycaesalpinioflavone and 7-methoxycaesalpinioflavone, as well as known derivatives rhuschalcone VI and caesalpinioflavone. Isolated compounds caused edema inhibition and neutrophil recruitment. Two of them showed better efficacy than reference drugs (indo...
Source: Molecules - Category: Chemistry Authors: Ol ívia da S. Domingos Bianca G. V. Alc ântara M ário F. C. Santos Tatiane C. S. Maiolini Danielle F. Dias Jo ão L. Baldim Jo ão Henrique G. Lago Marisi G. Soares Daniela A. Chagas-Paula Tags: Article Source Type: research