RGS21, a regulator of taste and mucociliary clearance?
Conclusions
Rgs21 is expressed in sinonsal mucosa, is amenable to purification as a recombinant protein, and can bind to Gαi/o/q subunits. Furthermore, RGS21 can accelerate the hydrolysis rate of GTP on Gαi subunits. This provides evidence that RGS21 may be a negative regulator of bitterant responses. Future studies will be needed to determine the physiological role of this protein in mucociliary clearance.
Level of EvidenceNA Laryngoscope, 2013
Source: The Laryngoscope - Category: ENT & OMF Authors: Adam J. Kimple, Alaina L. Garland, Staci P. Cohen, Vincent Setola, Francis S. Willard, Thomas Zielinski, Robert G. Lowery, Robert Tarran, David P. Siderovski Tags: Allergy/Rhinology Source Type: research