EP News: Basic and Translational

In the current study, Ardell et  al (JCI Insight 2019;pii:131648, PMID 31671074) investigate the mechanism underlying cardiac neural decentralization and spinal cord stimulation (SCS) in ischemia-induced ventricular fibrillation (VF) and sudden cardiac death (SCD) in a canine model using direct measurement of norepinephrine (NE) levels in the left ventricular interstitial fluid. Transient left anterior descending coronary artery occlusion (CAO) was performed. The authors demonstrate that during CAO, there was a 152% increase in NE level when the neuraxis was intact compared to 114% after intrathoracic neuraxial decentraliza tion (removal of the stellates) and 16% increase after intrinsic cardiac neuronal decentralization.

Source: Heart Rhythm - November 22, 2019 Category: Cardiology Authors: Nipavan Chiamvimonvat Source Type: research