Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Weihao Chen, Haiyi Liu, Jieyi Long, Huaming Tao, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Yonghong Liu, Junfeng WangAbstractAsperpentenone A (1), a novel polyketide with a rare cyclopentenone-tetrahydrofuran moiety, was isolated along with eight known compounds (2–9) from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and X-ray crystallography. Biological evaluation results revealed that kojic acid (3) showed weak antibacterial activities against Bacillus thuringiensis and Acinetobacter baumannii with MIC values of 32 and 128 μg/mL, respectively. Furthermore, griseofamine A (9) exhibited weak antibacterial activity with an MIC value of 64 μg/mL against Escherichia coli. The results of antibacterial experiments and especially the large yield of kojic acid (3) indicated that kojic acid might represent a candidate precursor for the development of antimicrobial agents.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research