Syndromic gastric polyposis and hereditary gastric cancers

Although the majority of gastric carcinomas are sporadic neoplasms, approximately 10% show familial aggregation, and a hereditary cause is determined in 1 –3% cases. Of these, hereditary diffuse gastric cancer (HDGC) is the most recognized predisposition syndrome. Although rare, some of the less commonly reported syndromes (including polyposis syndrome), also confer a markedly increased risk for development of gastric cancer. Identification and char acterization of these syndromes requires a multidisciplinary effort involving oncologists, surgeons, genetic counselors, and pathologists.

Source: Diagnostic Histopathology - November 21, 2019 Category: Pathology Authors: Till S. Clauditz, Michelle Moore, Namrata Setia, M.P. Kumarasinghe, Gregory Y. Lauwers Tags: Mini-symposium: Gastrointestinal/Hepato-Pancreato-Biliary Pathology Source Type: research