Effectiveness of intravenous isoniazid and ethambutol administration in patients with new smear positive drug-susceptible pulmonary tuberculosis with tuberculous meningoencephalitis and HIV co-infection in the intensive phase of treatment

Conclusions: As a result of the i/v administration of H and E, the basic clinical symptoms and X-ray signs of TM in the examined patients were more likely to reverse compared with those who were administered anti-TB drugs orally.I/v H and E chemotherapy during the intensive phase reduces the mortality rate of patients compared with the oral administration of the drugs mentioned above.I/v H and E administration is accompanied by significantly higher mean serum concentrations of drugs.I/v H and E administration in patients with TM does not cause additional side effects compared with the group2.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Butov, D., Feshchenko, Y., Kuzhko, M., Gumenuik, M., Kateryna, Y., Tkachenko, A., Nekrasova, N., Gulchuk, N., Tlustova, T., Butova, T. Tags: Tuberculosis Source Type: research