Decreased miR-150-5p and miR-23a-3p expressions in patients with active Pulmonary Tuberculosis (TB) disease

Conclusions: MiR-150-5p and miR-23a-3p were down-regulated in active TB disease. These findings provide biological insight into mechanisms by which Mycobacterium TB-suppressed miRs modulate human immunity, and indicate that over-expression of the miR-150 and miR-23a may be a new host-directed immunotherapy for active TB.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chen, Y.-C., Lin, M.-C., Lee, C.-P., Zheng, Y.-X., Fang, W.-F. Tags: Tuberculosis Source Type: research