Predictors of objective cough in patients with idiopathic pulmonary fibrosis (IPF)

Conclusion: Female gender and never-smoking status are predictive of cough severity measured by 24-h objective cough in IPF.TablePredictors of 24-h objective cough (n=41)PredictorsβRelative difference (95%CI)#P-valueUnivariateGender (female)FVC % predictedTLCOc % predictedTypical UIP pattern*Probable UIP pattern*Emphysema*Smoking status (never)PackyearsReflux0.8<-0.01<-0.1<-0.10.3-0.20.8<0.10.22.2 (1.1-4.4)1.0 (1.0-1.0)1.0 (1.0-1.0)0.9 (0.4-1.9)1.3 (0.6-2.9)0.8 (0.4-1.8)2.2 (1.2-3.9)1.0 (1.0-1.0)1.2 (0.7-1.8)0.040.80.20.80.50.6<0.010.30.5MultivariateModelGender (female)Smoking status (never)0.70.7R2=26%2.1 (1.0-3.9)2.0 (1.3-3.3)0.0040.0290.008#Bootstrapping (1.000 samples) was used to construct 95%CIs. *n=28, 2018 criteria. FVC, forced vital capacity;TLCO, transfer capacity of the lung for carbon monoxide;UIP, usual interstitial pneumonia

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: van Manen, M. J. G., Birring, S. S., Vancheri, C., Odink, A. E., Hussain, B., Vindigni, V., Renzoni, E., Russell, A.-M., Wapenaar, M., Cottin, V., Wijsenbeek, M. S. Tags: Idiopathic interstitial pneumonias Source Type: research