The Case | Severe symptomatic hypocalcemia in a  patient with sickle cell disease

A 46-year-old woman with a history of sickle cell disease and associated predialysis stage V chronic kidney disease (CKD) with secondary hyperparathyroidism presented with fever, severe extremity pain, and perioral numbness. On examination, she had a prominent Chvostek ’s sign, carpopedal spasm, hyperactive tendon reflexes, and a nontender mass in the left lobe of her thyroid gland. She was not on bisphosphonates or calcimimetics and had not been taking her prescribed calcitriol for 2 weeks.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research

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Publication date: February 2020Source: Annals of Emergency Medicine, Volume 75, Issue 2Author(s): Brandon J. Ricke, Bradley S. Jackson
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
Publication date: February 2020Source: Annals of Emergency Medicine, Volume 75, Issue 2Author(s): Taiju Miyagami, Yasuhiro Suyama, Yuichi Takahashi, Kwang-Seok Yang, Toshio Naito
Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
ConclusionIt is envisaged that the current review will add value to more scientific research on M. flabellifolius and enhance/promote the increased interest in the sustainable commercialization of M. flabellifolius herbal tea as well as lead to the validation of unverified ethnobotanical claims.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Crapé L, Strubbe B, Cesmeli E, de Clerck F Abstract A 24-year-old male presented with abdominal pain, postprandial vomiting and weight loss. Lab results showed an elevated serum eosinophil count and CT-scan demonstrated a thickened antral, duodenal and jejunal wall. Repetitive endoscopic mucosal biopsies were normal. Work-up of eosinophilia-associated gastro-intestinal disorders excluded secondary causes. Bone marrow showed an elevated eosinophil count without arguments for a primary hypereosinophilic syndrome. Endoscopic ultrasound-guided fine needle biopsy detected a strongly elevated number of eo...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Publication date: Available online 17 January 2020Source: Neuroscience LettersAuthor(s): Lauren M. Styczynski, Katie A. Schappacher, Mark L. BacceiAbstractEarly life administration of vincristine (VNC), commonly used to treat pediatric leukemia, evokes peripheral neuropathy and mechanical pain hypersensitivity in rats that lasts into adolescence. However, the degree to which VNC-evoked neuropathic pain persists throughout adulthood has yet to be examined. It also remains unclear if pediatric VNC exposure can ‘prime’ developing nociceptive pathways and thereby exacerbate chronic pain following subsequent trauma ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionThese results support the theory that underlying neurometabolite levels may be unique in different pain conditions and therefore representative of biomarkers for specific pain conditions.
Source: NeuroImage - Category: Neuroscience Source Type: research
aría Ruzafa-Martínez César Hueso-Montoro The aim of this article was to explore the experiences and attitudes of people with HIV/AIDS. A systematic review of qualitative studies was carried out. Twenty-seven articles were included, with sample sizes ranging from 3 to 78. Articles from North America, South America, Central America, Europe, and Africa were included. Five topics emerged from the synthesis: feelings about the diagnosis of HIV/AIDS; stigma and HIV/AIDS; changes in sexual behavior after becoming infected; living with the virus; and pregnancy and motherhood in seropositive women. The mo...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
ch Antoni Sanz Juan V. Luciano The study protocol of a prospective and randomized controlled trial for the assessment of the efficacy of nature activity therapy for people with Fibromyalgia (NAT-FM) is described. The primary outcome is the mean change from baseline in the Revised Fibromyalgia Impact Questionnaire (FIQR) score at post-treatment (12 weeks) and at 9 months of follow-up, and secondary outcomes are changes in the positive affect, negative affect, pain, fatigue, self-efficacy, catastrophising, and emotional regulation. A total of 160 patients with fibromyalgia will be divided into two arms: treatment-as-...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Protocol Source Type: research
In conclusion, the YQHX formula might retard the progression of kidney disease by activating autophagy. PMID: 31949466 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 14 January 2020Source: Chemical Engineering JournalAuthor(s): Keke Wu, Xiaoxian Wu, Meng Chen, Haoming Wu, Yanpeng Jiao, Changren ZhouAbstractInflammation or infectious wound could produce high level of hydrogen peroxide (H2O2), which may prevent wound healing process. It could be directly monitored the generated H2O2 to determine the wound microenvironment, which related to its healing status. Europium(III) Coordination Polymers (Eu CPs) had the ability to detect the level of H2O2 and promote wound healing. Thus, a H2O2-responsive smart dressing, fabricated by loading Eu CPs into polyacr...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
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