Glioma invasion and its interplay with nervous tissue and therapy: a multiscale model
Publication date: Available online 19 November 2019Source: Journal of Theoretical BiologyAuthor(s): Martina Conte, Luca Gerardo-Giorda, Maria GroppiAbstractA multiscale mathematical model for glioma cell migration and proliferation is proposed, taking into account a possible therapeutic approach. Starting with the description of processes occurring at the subcellular level, the equation for the mesoscopic level is formulated and a macroscopic model is derived, via parabolic limit and Hilbert expansions in the moment equations. After the model set up and the study of the well-posedness of this macroscopic setting, we investigate the role of the fibers in the tumor dynamics. In particular, we focus on the fiber density function, with the aim of comparing some common choices present in the literature and understanding which differences arise in the description of the actual fiber density and orientation. Finally, some numerical simulations, based on real data, highlight the role of each modelled process in the evolution of the solution of the macroscopic equation.
AbstractObjectivesTo investigate the value of contrast-enhanced (CE) turbo spin echo black blood (BB) sequences for imaging of therapy-naive high-grade gliomas (HGGs).MethodsConsecutive patients with histopathologically confirmed World Health Organization (WHO) grade III or IV gliomas and no oncological treatment prior to index imaging (March 2019 to January 2020) were retrospectively included. Magnetic resonance imaging (MRI) at 3 Tesla comprised CE BB and CE turbo field echo (TFE) sequences. The lack/presence of tumor-related contrast enhancement and satellite lesions were evaluated by two readers. Sharper delineat...
ConclusionsRibociclib administered following radiotherapy is feasible in DIPG and DMG. Increased tumor necrosis may represent a treatment effect. These data warrant further prospective volumetric analyses of tumors with necrosis. Feasibility and stabilization findings support further investigation of ribociclib in combination therapies.Trial registrationNCT02607124.
We present a case of LGI1 encephalitis only partially responsive to immunotherapy with eventual complete resolution after resection of a squamous cell lung carcinoma.
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.0c11878
Gliomas are a diverse group of primary central nervous system tumors with astrocytic, oligodendroglial, and/or ependymal features and are an important cause of morbidity/mortality in pediatric patients. Glioma classification relies on integrating tumor histology with key molecular alterations. This approach can help establish a diagnosis, guide treatment, and determine prognosis. New categories of pediatric glioma have been recognized in recent years, due to increasing application of molecular profiling in brain tumors. The aim of this review is to alert pediatric pathologists to emerging diagnostic concepts in pediatric g...
In the original publication, there are errors in Fig. 3D and Fig. 5C and are corrected as follows.
CONCLUSIONS: LINC00346/miR-128-3p/SZRD1 axis played a crucial role in modulating the malignant progression of glioma, which may serve as a prognostic indicator and a probable therapeutic target for glioma. PMID: 33015801 [PubMed - in process]
CONCLUSIONS: SUMO1P3 promotes glioma cell proliferation, migration, and invasion, and may be involved in Wnt/β-catenin signaling. PMID: 33015800 [PubMed - in process]