Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Conditions:   Keratoconus, Unstable;   Collagen Crosslinking;   Postoperative Pain Interventions:   Drug: Dextenza;   Drug: Prednisolone Acetate Sponsors:   Sight Medical Doctors PLLC;   Ocular Therapeutix, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Keratoconus, Unstable;   Collagen Crosslinking;   Postoperative Pain Interventions:   Drug: Dextenza;   Drug: Prednisolone Acetate Sponsors:   Sight Medical Doctors PLLC;   Ocular Therapeutix, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: In this case, intraocular E-PRP was a promising, apparently safe, and effective treatment option in management of corneal hydrops, in which conventional approaches failed. This is the first case in the literature to describe OCT appearance of corneal hydrops and intracameral use of E-PRP for the resolution of DM rupture in acute corneal hydrops.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
We report the first case of microbiologically proven Enterococcus faecium infection following deep anterior lamellar keratoplasty (DALK) and review the available literature. Patient concerns: A 37-years-old Caucasian man presented with pain, redness and severe vision loss in his right eye. Five weeks before, he underwent DALK using the FEMTO LDV Z8 in the same eye for the surgical correction of keratoconus. Diagnoses: Upon presentation, slit-lamp biomiscroscopy revealed corneal graft edema with multiple infiltrates located in the graft-host interface. Interventions: Therapeutic penetrating keratoplasty (PKP) was c...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
We describe a case that developed bilateral viral keratitis after corneal collagen crosslinking with riboflavin and ultraviolet A for progressive keratoconus.Case reportAn 18-year-old boy underwent corneal collagen crosslinking in both the eyes at the same setting for bilateral progressive keratoconus. He was discharged with a soft bandage contact lens and asked to follow up in 5  days. Seven days later, the patient returned with severe pain, redness, and photophobia for the last 2 days. The bandage contact lens was removed. There was a central corneal lesion in a branching dendritic pattern in both the eyes ...
Source: Journal of Ophthalmic Inflammation and Infection - Category: Opthalmology Source Type: research
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print.
Source: Journal of Ocular Pharmacology and Therapeutics - Category: Opthalmology Authors: Source Type: research
ConclusionDisturbing visual palinopsia and afterimages can occur followingin vitro fertilization treatment for infertility due to increased estrogen levels. This rare ocular side effect caused byin vitro fertilization treatment is not reported in the literature to the best of our knowledge. Gynecologists and/or infertility experts should educate their patients regarding these possible ocular symptoms. Even ophthalmologists should be aware of this rare cause for visual palinopsia.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 7 May 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Mouhamed A. Al Aqaba, Virinder K. Dhillon, Imran Mohammed, Dalia G. Said, Harminder S. DuaAbstractThe cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cells. The nerves destined for the cornea travel from the trigeminal ganglion in a complex and coordinated manner to terminate between and within corneal epithelial cells with which the...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
We describe four cases of sterile infiltrates after uneventful S-CXL for keratoconus, from diagnosis to medical management with six months of follow-up, reporting their pathophysiological features, and comparing our findings with published reports. We discuss various possibilities for diagnosing sterile infiltration more rapidly. In terms of the pathophysiology of sterile infiltrate formation, we separated our patients into two types, one with sterile infiltrate from an antigen reaction and the other with sterile infiltrate due to excessive scarring. Early local steroid treatment resulted in a good visual outcome in our ca...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
ConclusionsSubepithelial accelerated CXL significantly improved postoperative pain as well as reduced the epithelial healing time for the treatment of keratoconus.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
This study provides histological evidence that ionto-CXL may represent a non-invasive alternative in the management of progressive keratoconus in adults. PMID: 28215504 [PubMed - as supplied by publisher]
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Acta Histochem Source Type: research
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